CC-401|862832-38-0 (free base)--Shanghai xingMo Biotechnology

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Description

CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Based on the chemistry of SP600125, another anthrapyrazolone inhibitor of JNK, CC-401 competitively binds the ATP binding site of JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of transcription factor c-Jun; decreased transcription activity of c-Jun; and a variety of cellular effects including decreased cellular proliferation.

Chemical Structure

Chemical Name

3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

SMILES Code

C1(C2=CC=CC(OCCN3CCCCC3)=C2)=NNC4=C1C=C(C5=NC=NN5)C=C4

Theoretical Analysis

XingMo Cat#:XM121
Product Name:CC-401
Synonyms:CC401; CC 401; CC-401.
CAS#:862832-38-0 (free base)
Chemical Formula:C₂₂H₂₄N₆O
Exact Mass:388.20116
Molecular Weight:388.46

Technical Data

Appearance: solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

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