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Description
Lirafugratinib (RLY-4008) 是一种具有口服活性、不可逆、高选择性 FGFR2 抑制剂,IC50 为 3 nM。Lirafugratinib 与 Cys491 共价结合。Lirafugratinib 靶向 FGFR2 改变和耐药突变,诱导肿瘤消退,同时不影响其他 FGFR。 
Chemical Structure
 
Chemical Name
2-Propenamide, N-[4-[4-amino-5-[3-fluoro-4-[(4-methyl-2-pyrimidinyl)oxy]phenyl]-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methyl- 
Theoretical Analysis
XingMo Cat#:XM806 
Product Name:Lirafugratinib 
Synonyms:RLY-4008 
CAS#:2549174-42-5 
Chemical Formula:C28H24FN7O2 
Exact Mass:509.55 
Molecular Weight:509.55 
Purity:98% 
Technical Data

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

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