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| Description |
| M7583 is a potent, orally administered, highly selective, adenosine triphosphate (ATP)-competitive, second generation, irreversible inhibitor of BTK. Kinase specificity has been determined in vitro using the Merck Millipore Kinase Profiler panel. Only 3 kinases (Blk, BMX, and Txk) had IC50s within a 10-fold range of BTK (BTK IC50 = 18.5 nM; Blk IC50 = 77 nM; BMX IC50= 5 nM; Txk IC50 = 62 nM). |
| Chemical Structure |
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| Chemical Name |
| 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-4-fluoropiperidin-1-yl)prop-2-en-1-one, 1-(4-{[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino]methyl}-4-fluoropiperidin-1-yl)prop-2-en-1 |
| Theoretical Analysis |
XingMo Cat#:XM800
Product Name:TL-895, M7583
Synonyms:M7583,M-7583
CAS#:1415823-49-2
Chemical Formula:C25H26FN5O2
Molecular Weight:447.512
Purity:98%
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| Technical Data |
Solubility: Soluble in DMSO, not in water
Shelf Life:
>2 years if stored properly.
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months). |
WARNING: This product is for research use only, not for human or veterinary use
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