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Description |
Debio 0123 is a Wee1 kinase inhibitor. Wee1 is a key regulator of the G2/M and S phase checkpoints, activated in response to DNA damage, to allow cells to repair their DNA before resuming cycling. Inhibition of Wee1, particularly in combination with DNA damaging agents, induces an overload of DNA breaks, and in conjunction with abrogation of other checkpoints, such as G1 controlled by p53, pushes the cells through cycle without DNA repair, promotes mitotic catastrophe and induces apoptosis of cancer cells. |
Chemical Structure |
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Chemical Name |
Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- |
Theoretical Analysis |
XingMo Cat#:XM799 Product Name:Debio-0123 Synonyms:Debio-0123,Debio0123 CAS#:2243882-74-6 Chemical Formula:C26H28Cl2N6O Molecular Weight:511.45 Purity:98%
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Technical Data |
Solubility: Soluble in DMSO, not in water
Shelf Life:
>2 years if stored properly.
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months). |
WARNING: This product is for research use only, not for human or veterinary use
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