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Description
Debio 0123 is a Wee1 kinase inhibitor. Wee1 is a key regulator of the G2/M and S phase checkpoints, activated in response to DNA damage, to allow cells to repair their DNA before resuming cycling. Inhibition of Wee1, particularly in combination with DNA damaging agents, induces an overload of DNA breaks, and in conjunction with abrogation of other checkpoints, such as G1 controlled by p53, pushes the cells through cycle without DNA repair, promotes mitotic catastrophe and induces apoptosis of cancer cells. 
Chemical Structure
 
Chemical Name
Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- 
Theoretical Analysis
XingMo Cat#:XM799 
Product Name:Debio-0123 
Synonyms:Debio-0123,Debio0123 
CAS#:2243882-74-6 
Chemical Formula:C26H28Cl2N6O 
Molecular Weight:511.45 
Purity:98% 
Technical Data

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

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