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Description
LYC-55716 (Cintirorgon) is a first-in-class, selective, orally active RORγ agonist, modulates expression of genes that promote immune responses; reduces PD-1 expression in vitro and in vivo after adoptive cell transfer, relieves PD-1/PD-L1 inhibition of proliferation and IFNγ; significantly augments anti-tumor activity of doxorubicin, results in immune-dependent decreased tumor growth and enhanced survival in preclinical models of cancer. 
Chemical Structure
 
Chemical Name
(S)-3-(6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid 
Theoretical Analysis
XingMo Cat#:XM768 
Product Name:LYC-55716 
Synonyms:LYC-55716,LYC55716 
CAS#:2055536-64-4 
Chemical Formula:C27H23F6NO6S 
Exact Mass:603.532 
Molecular Weight:603.53 
Purity:98% 
Technical Data

Appearance: solid powder         

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

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