+86-13524779951 sales@xmobio.com
Products
  BIOACTIVE COMPOUND
  Anti-tumor series
  Antithrombotic series
  Anti-HCV series
  Rheumatism series
  Anti-diabetic series
  Nervous system series
  Others
  intermediate
  Featured products
  Others

This product is in stock,please ask for price.
If you have any question, please send the email to sales@xmobio.com for the availability.We will reply to you as soon as possible.
Shipment: Products are shipped via FedEx Express.
Products
Description
CFI-401870 is a orally bioavailable, potent tyrosine threonine kinase (TTK) Inhibitor (TTK IC50 < 10 nM, HCT116 GI50 < 0.1 μM). CFI-401870 displayed low off-target activity (>500×), and microsomal stability (T(1/2) > 30 min). CFI-401870 recapitulated the phenotype of TTK RNAi, demonstrated in vivo tumor growth inhibition upon oral dosing, and was selected for preclinical evaluation. 
Chemical Structure
 
Chemical Name
N-((R)-cyclopropyl(pyridin-2-yl)methyl)-3-(4-((1R,3R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5-carboxamide 
SMILES Code
O[C@H]1C[C@H](N2C3=CC=C(C4=NNC5=C4C=C(C(N[C@@H](C6=NC=CC=C6)C7CC7)=O)C=C5)C=C3)CC[C@H]2C1 
Theoretical Analysis
XingMo Cat#:XM095 
Product Name:CFI-401870 
Synonyms:CFI-401870; CFI 401870; CFI401870 
CAS#:1430741-35-7 (free base) 
Chemical Formula:C30H31N5O2 
Exact Mass:493.2478 
Molecular Weight:493.611 
Technical Data

Appearance: Solid powder                               

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

Tel: +8613524779951  QQ: 点击这里给我发消息
Email: sales@xmobio.com   Web: www.xmobio.com  沪ICP备17047952号-1
Copyright 2017 Shanghai xingMo Biotechnology Co., Ltd. All rights reserved. Supported by www.hxchem.net