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Shipment: Products are shipped via FedEx Express. |
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| Description |
| Merestinib, also known as LY2801653, is a n orally available, small molecule inhibitor of the proto-oncogene c-Met (mesenchymal-epithelial transition, also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor LY2801653 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. This agent has potent anti-tumor efficacy in mono- and combination therapy in a broad range of cancers. |
| Chemical Structure |
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| Chemical Name |
| N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide |
| SMILES Code |
| O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3 |
| Theoretical Analysis |
XingMo Cat#:XM706
Product Name:Merestinib (LY2801653)
Synonyms:LY-2801653; LY 2801653; LY2801653; Merestinib
CAS#:1206799-15-6 (free base)
Chemical Formula:C30H22F2N6O3
Exact Mass:552.17215
Molecular Weight:552.53
Purity:>98%
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| Technical Data |
Appearance: Solid powder
Purity: >98%
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4o for short term (days to weeks) or -20oC for long term (months to years).
Solubility: Soluble in DMSO, not in water |
WARNING: This product is for research use only, not for human or veterinary use
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