+86-13524779951 sales@xmobio.com
Products
  BIOACTIVE COMPOUND
  Anti-tumor series
  Antithrombotic series
  Anti-HCV series
  Rheumatism series
  Anti-diabetic series
  Nervous system series
  Others
  intermediate
  Featured products
  Others

This product is in stock,please ask for price.
If you have any question, please send the email to sales@xmobio.com for the availability.We will reply to you as soon as possible.
Shipment: Products are shipped via FedEx Express.
Products
Description
SW044248 is a potent and selective Topoisomerase I inhibitor. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortalized human bronchial cell lines. The acute transcriptional response to SW044248 in sensitive HCC4017 cells correlated significantly with inhibitors of topoisomerases and SW044248 inhibited topoisomerase 1 (Top1) but not topoisomerase 2. SW044248 inhibited Top1 differently from camptothecin and camptothecin did not show the same selective toxicity as SW044248. Elimination of Top1 by siRNA partially protected cells from SW044248, although removing Top1 was itself eventually toxic. 
Chemical Structure
 
Chemical Name
2-((5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(2-methoxyphenyl)butanamide 
SMILES Code
CCN1C2=CC=CC=C2C3=C1N=C(N=N3)SC(C(NC4=CC=CC=C4OC)=O)CC 
Theoretical Analysis
XingMo Cat#:XM476 
Product Name:SW044248 
Synonyms:SW044248; SW-044248; SW 044248 
CAS#:522650-83-5 
Chemical Formula:C22H23N5O2S 
Exact Mass:421.1572 
Molecular Weight:421.519 
Purity:>98% 
Technical Data

Appearance: solid powder         

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

Tel: +8613524779951  QQ: 点击这里给我发消息
Email: sales@xmobio.com   Web: www.xmobio.com  沪ICP备17047952号-1
Copyright 2017 Shanghai xingMo Biotechnology Co., Ltd. All rights reserved. Supported by www.hxchem.net