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Description
Voxelotor, also known as GBT-440, is a hemoglobin S allosteric modulator. GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. 
Chemical Structure
 
Chemical Name
2-hydroxy-6-({2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl}methoxy)benzaldehyde 
SMILES Code
O=CC1=C(OCC2=CC=CN=C2C3=CC=NN3C(C)C)C=CC=C1O 
Theoretical Analysis
XingMo Cat#:XM438 
Product Name:Voxelotor 
Synonyms:Voxelotor; GBT-440; GBT 440; GBT440; GTx-011; GTx011; GTx 011 
CAS#:1446321-46-5 
Chemical Formula:C19H19N3O3 
Exact Mass:337.1426 
Molecular Weight:337.379 
Technical Data

Appearance: Solid powder                         

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 oC for short term (days to weeks), or -20 oC for long term (months). 

 



WARNING: This product is for research use only, not for human or veterinary use

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