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Description
PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively. ACC inihibitors inhibit de novo lipogenesis and increase β-oxidation of long-chain fatty acids with potential for treatment of type 2 diabetes, hepatic steatosis, and cancer. 
Chemical Structure
 
Chemical Name
1,4-Dihydro-1’-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4’-piperidin]-7(6H)-one 
SMILES Code
O=C1CC2(CCN(C(C3=CC=C4N=C(C)NC4=C3)=O)CC2)CC5=C1N(C(C)C)N=C5 
Theoretical Analysis
XingMo Cat#:XM418 
Product Name:PF 05175157 
Synonyms:PF-05175157; PF05175157; PF 05175157. 
CAS#:1301214-47-0 
Chemical Formula:C23H27N5O2 
Exact Mass:405.21648 
Molecular Weight:405.5 
Purity:>98% 
Technical Data

Appearance: solid powder                       

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

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