DAPT|208255-80-5--Shanghai xingMo Biotechnology

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Description

DAPT, also known GSI-IX, is a potent and selective γ-secretase inhibitor. DAPT is a non-transition-state analogue GSI and is the compound most widely evaluated in experimental models. DAPT causes a reduction in Aβ levels in human primary neuronal cell cultures with IC50 values = 115−200 nM. DAPT blocks Notch signaling in a cell-based assay measuring the activation of the Notch pathway reporter gene with an IC50 = 500 nM. As an inhibitor of Notch, DAPT has also been used in the study of autoimmune and lymphoproliferative diseases.

Chemical Structure

Chemical Name

tert-butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate

SMILES Code

O=C(OC(C)(C)C)[C@H](C1=CC=CC=C1)NC([C@H](C)NC(CC2=CC(F)=CC(F)=C2)=O)=O

Theoretical Analysis

XingMo Cat#:XM196
Product Name:DAPT
Synonyms:DAPT; DAPT peptide; GSI-IX; GSI IX; N-(2FPhAc)Ala-phenyl-Gly t-butyl ester
CAS#:208255-80-5
Chemical Formula:C₂₃H₂₆F₂N₂O₄
Exact Mass:432.1861
Molecular Weight:432.4678
Purity:>98%

Technical Data

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4oC for short term (days to weeks), or -20oC for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

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