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Description
BAY 41-2272 is a a soluble guanylate cyclase stimulator (sGC stimulator). BAY 41-2272 inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle.2,3 BAY 41-2272 is effective in vivo. BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats. 
Chemical Structure
 
Chemical Name
5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine 
SMILES Code
NC1=NC(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)=NC=C1C5CC5 
Theoretical Analysis
XingMo Cat#:XM439 
Product Name:BAY 41-2272 
Synonyms:BAY 41-2272; BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272. 
CAS#:256376-24-6 
Chemical Formula:C20H17FN6 
Exact Mass:360.1499 
Molecular Weight:360.3964 
Purity:>98% 
Technical Data
Appearance: Solid powder 
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)
Solubility: Soluble in DMSO, not in water
Shelf Life:
>2 years if stored properly.
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4 oC for short term (days to weeks), or -20 oC for long term (months).
 



WARNING: This product is for research use only, not for human or veterinary use

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