MK-2206 2HCl|1032350-13-2 (2HCl), 1032349-77-1 (HCl);1032349-93-1 (free base).--Shanghai xingMo Biotechnology

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Description

MK2206 is a Akt inhibitor, is also an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.

Chemical Structure

Chemical Name

8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-8,9-dihydro-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride

SMILES Code

O=C1NN=C2C3=CC(C4=CC=CC=C4)C(C5=CC=C(C6(N)CCC6)C=C5)N=C3C=CN21.[H]Cl.[H]Cl

Theoretical Analysis

XingMo Cat#:XM055
Product Name:MK-2206 2HCl
Synonyms:MK2206; MK-2206; MK 2206; MK2206 dihydrochloride; MK2206 HCl.
CAS#:1032350-13-2 (2HCl), 1032349-77-1 (HCl);1032349-93-1 (free base).
Chemical Formula:C₂₅H₂₅Cl₂N₅O
Exact Mass:481.14362
Molecular Weight:409.48483
Purity:>98%

Technical Data

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

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