PLX8394|1393466-87-9--Shanghai xingMo Biotechnology

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Description

PLX8394 is an orally bioavailable inhibitor of serine/threonine-protein kinase B-raf (BRAF) protein with potential antineoplastic activity. PLX8394 appears to selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, which may subsequently inhibit the proliferation of tumor cells which express mutated forms of BRAF. PLX8394 appears to be effective against tumors that express multiple mutated forms of the kinase and may be an effective therapeutic agent for tumors that are resistant to other BRAF inhibitor therapies that are specific for the BRAF V600E mutant.

Chemical Structure

Chemical Name

(R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide

SMILES Code

O=S(N1C[C@H](F)CC1)(NC2=CC=C(F)C(C(C3=CNC4=NC=C(C5=CN=C(C6CC6)N=C5)C=C43)=O)=C2F)=O

Theoretical Analysis

XingMo Cat#:XM054
Product Name:PLX8394
Synonyms:PLX8394; PLX-8394; PLX 8394.
CAS#:1393466-87-9
Chemical Formula:C₂₅H₂₁F₃N₆O₃S
Exact Mass:542.13479
Molecular Weight:542.54
Purity:>98%

Technical Data

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

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