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| Description |
| AZ960 is a novel inhibitor of Jak2 kinase. AZ960 inhibits JAK2 kinase with a K(i) of 0.00045 microm in vitro and treatment of TEL-JAK2 driven Ba/F3 cells with AZ960 blocked STAT5 phosphorylation and potently inhibited cell proliferation (GI(50)=0.025 microm). AZ960 demonstrated selectivity for TEL-JAK2-driven STAT5 phosphorylation and cell proliferation when compared with cell lines driven by similar fusions of the other JAK kinase family members. |
| Chemical Structure |
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| Chemical Name |
| (S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile |
| SMILES Code |
| N#CC1=C(N[C@H](C2=CC=C(F)C=C2)C)N=C(NC3=NNC(C)=C3)C(F)=C1 |
| Theoretical Analysis |
XingMo Cat#:XM052
Product Name:AZ-960
Synonyms:AZ960; AZ 960; AZ-960.
CAS#:905586-69-8
Chemical Formula:C18H16F2N6
Exact Mass:354.14045
Molecular Weight:354.36
Purity:>98%
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| Technical Data |
WARNING: This product is for research use only, not for human or veterinary use
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