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Description
PF-04217903 is a MET tyrosine kinase inhibitor, is also an orally bioavailabe, small-molecule tyrosine kinase inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor PF-04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met. 
Chemical Structure
 
Chemical Name
2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol 
SMILES Code
OCCN1N=CC(C2=CN=C3C(N(CC4=CC=C5N=CC=CC5=C4)N=N3)=N2)=C1 
Theoretical Analysis
XingMo Cat#:XM471 
Product Name:PF-04217903 
Synonyms:PF04217903; PF 04217903; PF-04217903; PF4217903; PF-4217903; PF 4217903. 
CAS#:956905-27-4 (free base); 956906-93-7 (mesylate) 
Chemical Formula:C19H16N8O 
Exact Mass:372.14471 
Molecular Weight:372.38 
Technical Data

Appearance: White solid powder                                    

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 oC for short term (days to weeks), or -20 oC for long term (months). 

 



WARNING: This product is for research use only, not for human or veterinary use

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