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| Description |
| BAY 41-2272 is a a soluble guanylate cyclase stimulator (sGC stimulator). BAY 41-2272 inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle.2,3 BAY 41-2272 is effective in vivo. BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats. |
| Chemical Structure |
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| Chemical Name |
| 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine |
| SMILES Code |
| NC1=NC(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)=NC=C1C5CC5 |
| Theoretical Analysis |
XingMo Cat#:XM465
Product Name:BAY 41-2272
Synonyms:BAY 41-2272; BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272.
CAS#:256376-24-6
Chemical Formula:C20H17FN6
Exact Mass:360.1499
Molecular Weight:360.3964
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| Technical Data |
WARNING: This product is for research use only, not for human or veterinary use
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