Olmutinib free base|1353550-13-6 (free base)--Shanghai xingMo Biotechnology

+86-13524779951

sales@xmobio.com

Products

BIOACTIVE COMPOUND

Anti-tumor series

Antithrombotic series

Anti-HCV series

Rheumatism series

Anti-diabetic series

Nervous system series

Others

intermediate

Featured products

Others

This product is in stock，please ask for price.
If you have any question, please send the email to sales@xmobio.com for the availability.We will reply to you as soon as possible.
Shipment: Products are shipped via FedEx Express.

Products

Description

Olmutinib, also known as HM61713 and BI-1482694, is a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK). BTK is a member of the Tec family of non-receptor protein tyrosine kinases. BTK is mostly expressed in hematopoietic cells such as B cells, mast cells and macrophages. BTK plays key roles in multiple cell signaling pathways including B-Cell Receptor (BCR) and Fc receptor (FcR) signaling cascades and is an essential mediator not only in B-cell dependent but also in myeloid cell dependent inflammatory arthritis. HM71224 has been selected as a novel therapeutic agent for the treatment of autoimmune diseases such as RA.

Chemical Structure

Chemical Name

N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

SMILES Code

C=CC(NC1=CC=CC(OC2=C3C(C=CS3)=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1)=O

Theoretical Analysis

XingMo Cat#:XM440
Product Name:Olmutinib free base
Synonyms:HM61713; HM 61713; HM-61713; BI 1482694; BI-1482694; BI1482694; Olmutinib.
CAS#:1353550-13-6 (free base)
Chemical Formula:C₂₆H₂₆N₆O₂S
Exact Mass:486.18379
Molecular Weight:486.59

Technical Data

Appearance: Light yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ^oC for short term (days to weeks), or -20 ^oC for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

Tel: +8613524779951 QQ: