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Description
Serdemetan, also known as JNJ-26854165, is an orally bioavailable, small-molecule HDM2 antagonist with potential antineoplastic activity. HDM2 antagonist JNJ-26854165 inhibits the binding of the HDM2–p53 complex to the proteasome, blocking the degradation of p53; p53 signaling and p53-mediated induction of tumor cell apoptosis may thus be restored. In addition to p53, degradation of other HDM2 client proteins may be inhibited. 
Chemical Structure
 
Chemical Name
N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine 
SMILES Code
C1(NCCC2=CNC3=C2C=CC=C3)=CC=C(NC4=CC=NC=C4)C=C1 
Theoretical Analysis
XingMo Cat#:XM394 
Product Name:Serdemetan (JNJ26854165) 
Synonyms:JNJ26854165; JNJ-26854165; JNJ 26854165; Serdemetan. 
CAS#:881202-45-5 
Chemical Formula:C21H20N4 
Exact Mass:328.1688 
Molecular Weight:328.41 
Technical Data

Appearance: white solid powder              

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 oC for short term (days to weeks), or -20 oC for long term (months). 

 



WARNING: This product is for research use only, not for human or veterinary use

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