Cobimetinib|934660-93-2 (free base)--Shanghai xingMo Biotechnology

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Description

Cobimetinib, also known as GDC-0973 and XL-518 , is an orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor GDC-0973 specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types.

Chemical Structure

Chemical Name

(S)-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-(piperidin-2-yl)cyclobutyl)methanone.

SMILES Code

O=C(C1=CC=C(F)C(F)=C1NC2=CC=C(I)C=C2F)C3CC([C@H]4NCCCC4)(O)C3

Theoretical Analysis

XingMo Cat#:XM381
Product Name:Cobimetinib
Synonyms:XL518; XL 518; XL-518; GDC0973; GDC 0973; GDC-0973; cobimetinib
CAS#:934660-93-2 (free base)
Chemical Formula:C₂₂H₂₂F₃IN₂O₂
Exact Mass:530.06781
Molecular Weight:530.32196

Technical Data

Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

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