Description

WP1066 is a Stat3 inhibitor and JAK2 inhibitor. WP1066 is also a novel analogue of the JAK2 inhibitor AG490, in JAK2 V617F-positive erythroleukemia HEL cells and in blood cells from patients with polycythemia vera. WP1066 significantly inhibited JAK2 and its downstream signal transducer and activator of transcription-3, signal transducer and activator of transcription-5, and extracellular signal-regulated kinase-1/2 pathways in a dose- and time-dependent manner. WP1066 is active both in vitro and ex vivo and should be further developed for the treatment of neoplasms expressing the JAK2 V617F mutation.

Chemical Structure

Chemical Name

(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide

SMILES Code

O=C(N[C@H](C1=CC=CC=C1)C)/C(C#N)=C/C2=NC(Br)=CC=C2

Theoretical Analysis

XingMo Cat#:XM365  Product Name:WP1066  Synonyms:WP1066; WP 1066; WP-1066  CAS#:857064-38-1  Chemical Formula:C17H14BrN3O  Exact Mass:355.03202  Molecular Weight:356.22

Technical Data

WARNING: This product is for research use only, not for human or veterinary use