ND-646|1434639-57-2--Shanghai xingMo Biotechnology

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Description

ND-646 is-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC. ND-646 had enhanced efficacy when combined with carboplatin, a common component of chemotherapeutic regimens used to treat human NSCLC.

Chemical Structure

Chemical Name

2-(1-((R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4,4a,7a-tetrahydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanamide

SMILES Code

COC1=CC=CC=C1[C@H](CN2C(N(C(C)(C)C(N)=O)C(C3C2SC(C4=NC=CO4)=C3C)=O)=O)OC5CCOCC5

Theoretical Analysis

XingMo Cat#:XM348
Product Name:ND-646
Synonyms:ND-646; ND 646; ND646.
CAS#:1434639-57-2
Chemical Formula:C₂₈H₃₄N₄O₇S
Exact Mass:570.2148
Molecular Weight:570.661

Technical Data

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

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