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Description
Semaxanib, also known as SU5416, is a quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. 
Chemical Structure
 
Chemical Name
(Z)-3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one 
SMILES Code
O=C1NC2=C(C=CC=C2)/C1=C/C3=C(C)C=C(C)N3 
Theoretical Analysis
XingMo Cat#:XM322 
Product Name:Semaxanib 
Synonyms:SU5416; SU-5416; SU 5416; Sugen 5416; semoxind; Semaxanib 
CAS#:204005-46-9 
Chemical Formula:C15H14N2O 
Exact Mass:238.11061 
Molecular Weight:238.28 
Technical Data

Appearance: Yellow to orange solid powder r                            

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).o-bidi-language:AR-SA;font-weight:normal'>C for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

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