GS-9901|1640247-87-5--Shanghai xingMo Biotechnology

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Description

GS-9901 is a potent, orally active and highly selective inhibitor of PI3Kδ (PI3Kdelta IC50 = 1.0nM, HWB delta EC50 = 1.5 nM; CLpr hHep = 0.05 L/h/kg.). GS-9901 displays an excellent pharmacokinetic profile and is efficacious in a rodent model of rheumatoid arthritis. GS-9901 demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans. The favorable in vitro and in vivo attributes of GS-9901 resulted in its selection as a development candidate.

Chemical Structure

Chemical Name

(S)-2,4-diamino-6-(((5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile

SMILES Code

N#CC1=C(N)N=C(N)N=C1N[C@@H](C2CC2)C(N3C4=CC=CN=C4)=NC5=C(C(Cl)=CC=C5F)C3=O

Theoretical Analysis

XingMo Cat#:XM316
Product Name:GS-9901
Synonyms:GS-9901; GS 9901; GS9901.
CAS#:1640247-87-5
Chemical Formula:C₂₂H₁₇ClFN₉O
Exact Mass:477.1229
Molecular Weight:477.8884

Technical Data

Related CAS #: 1640247-87-5 (GS-9901) 1640248-45-8 (GS-9901 R-isomer)

Appearance: solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years)

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

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