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Description
BAY1143572 is a highly selective, potent and orally available inhibitor of PTEFb/CDK9 currently in Phase I. BAY1143572 inhibits MYC and shows convincing anti-tumor activity in multiple xenograft models by the induction of apoptosis. BAY 1143572 had potent and highly selective PTEFb-kinase inhibitory activity in the low nanomolar range against PTEFb/CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY 1143572 also showed single agent in vivo efficacy at tolerated doses in various xenograft tumor models in mice and rats upon once daily oral administration. 
Chemical Structure
 
Theoretical Analysis
XingMo Cat#:XM284 
Product Name:BAY1143572 
Synonyms:BAY1143572; BAY 1143572; BAY-1143572. 
CAS#:1414943-88-6 
Chemical Formula:C₁₈H₁₈FN₅O₂S 
Exact Mass:387.54 
Molecular Weight:387.43 
Purity:>98% 
Technical Data

Appearance: Solid powder                       

Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

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