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Description
JNJ-26483327, also known as BGB102, is an orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). 
Chemical Structure
 
Chemical Name
35-bromo-17-methoxy-5-methyl-11-oxa-2,5-diaza-1(4,6)-quinazolina-3(1,2)-benzenacycloundecaphan 
SMILES Code
CN1CCCCCOC(C(OC)=C2)=CC3=C2N=CN=C3NC4=CC(Br)=CC=C4C1 
Theoretical Analysis
XingMo Cat#:XM246 
Product Name:JNJ-26483327 
Synonyms:JNJ26483327; JNJ 26483327; JNJ-26483327; BGB102; BGB-102; BGB 102. 
CAS#:807640-87-5 (free base); 1021686-80-5 (2HBr salt). 
Chemical Formula:C22H25BrN4O2 
Exact Mass:456.11609 
Molecular Weight:457.3635 
Technical Data

Appearance: white solid powder           

Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

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