TAK-580 (MLN2480)|1096708-71-2--Shanghai xingMo Biotechnology

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Description

TAK-580, also known as MLN2480, BIIB024, and AMG 2112819, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.

Chemical Structure

Chemical Name

(R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide

SMILES Code

O=C(C1=CN=C([C@H](NC(C2=NC=NC(N)=C2Cl)=O)C)S1)NC3=NC=C(Cl)C(C(F)(F)F)=C3

Theoretical Analysis

XingMo Cat#:XM232
Product Name:TAK-580 (MLN2480)
Synonyms:TAK-580; TAK 580; TAK580; MLN 2480; MLN-2480; MLN2480; BIIB024, BIIB 024, BIIB-024; AMG 2112819; AMG2112819; AMG-2112819.
CAS#:1096708-71-2
Chemical Formula:C₁₇H₁₂Cl₂F₃N₇O₂S
Exact Mass:505.01023
Molecular Weight:506.29

Technical Data

Appearance: solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 ℃ for short term (days to weeks), or -20 ℃ for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

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