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Shipment: Products are shipped via FedEx Express. |
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| Description |
| RO4929097, also known as RO04929097, is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth. |
| Chemical Structure |
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| Chemical Name |
| (S)-2,2-dimethyl-N1-(6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N3-(2,2,3,3,3-pentafluoropropyl)malonamide |
| SMILES Code |
| O=C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O)C(C)(C)C(NCC(F)(F)C(F)(F)F)=O |
| Theoretical Analysis |
XingMo Cat#:XM199
Product Name:RO4929097
Synonyms:R4733; R 4733; R-4733; RO4929097; RO-4929097; RO 4929097; RO04929097; RO-04929097; RO 04929097.
CAS#:847925-91-1
Chemical Formula:C22H20F5N3O3
Exact Mass:469.14248
Molecular Weight:469.40452
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| Technical Data |
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life:
>2 years if stored properly.
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4oC for short term (days to weeks), or -20oC for long term (months). |
WARNING: This product is for research use only, not for human or veterinary use
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