Afuresertib HCl|1047645-82-8 (HCl); 1047644-62-1 (free base).--Shanghai xingMo Biotechnology

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Description

Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Chemical Structure

Chemical Name

N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride

SMILES Code

O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)S1)N[C@@H](CC3=CC=CC(F)=C3)CN.[H]Cl

Theoretical Analysis

XingMo Cat#:XM191
Product Name:Afuresertib HCl
Synonyms:GSK2110183; GSK 2110183; GSK-2110183; GSK2110183B; GSK 2110183B; GSK2110183B; Afuresertib.
CAS#:1047645-82-8 (HCl); 1047644-62-1 (free base).
Chemical Formula:C₁₈H₁₈Cl₃FN₄OS
Exact Mass:463.78
Molecular Weight:463.78

Technical Data

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4^oC for short term (days to weeks), or -20^oC for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

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