Pilaralisib (XL-147)|934526-89-3 (or 956958-53-5)--Shanghai xingMo Biotechnology

+86-13524779951

sales@xmobio.com

Products

BIOACTIVE COMPOUND

Anti-tumor series

Antithrombotic series

Anti-HCV series

Rheumatism series

Anti-diabetic series

Nervous system series

Others

intermediate

Featured products

Others

This product is in stock，please ask for price.
If you have any question, please send the email to sales@xmobio.com for the availability.We will reply to you as soon as possible.
Shipment: Products are shipped via FedEx Express.

Products

Description

Pilaralisib, also known as XL147, is a Class 1 PI3K kinase family inhibitor, and is a n orally bioavailable small molecule, targeting the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Class 1 PI3K kinase family inhibitor XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis.

Chemical Structure

Chemical Name

2-amino-N-(3-(N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-2-methylpropanamide.

SMILES Code

CC(C)(N)C(NC1=CC=CC(S(=O)(NC2=NC3=CC=CC=C3N=C2NC4=CC(OC)=CC=C4Cl)=O)=C1)=O

Theoretical Analysis

XingMo Cat#:XM179
Product Name:Pilaralisib (XL-147)
Synonyms:XL147; XL 147; XL-147; SAR245408; SAR-245408; SAR 245408; Pilaralisib.
CAS#:934526-89-3 (or 956958-53-5)
Chemical Formula:C₂₅H₂₅ClN₆O₄S
Exact Mass:540.13465
Molecular Weight:541.02

Technical Data

Appearance: solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

Tel: +8613524779951 QQ: