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Shipment: Products are shipped via FedEx Express. |
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| Description |
| BGB-324, also known as R428, is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. |
| Chemical Structure |
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| Chemical Name |
| (S)-1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine |
| SMILES Code |
| NC1=NC(NC2=CC=C3C(CC[C@@H](N4CCCC4)CC3)=C2)=NN1C5=NN=C6C(CCCC7=CC=CC=C76)=C5 |
| Theoretical Analysis |
XingMo Cat#:XM150
Product Name:BGB324 (R428)
Synonyms:BGB324 ; BGB-324 ; BGB 324 ; R 428 R 428 R428.
CAS#:1037624-75-1
Chemical Formula:C30H34N8
Exact Mass:506.29064
Molecular Weight:506.64
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| Technical Data |
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life:
>2 years if stored properly.
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
WARNING: This product is for research use only, not for human or veterinary use
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