Enasidenib (AG-221)|1446502-11-9--Shanghai xingMo Biotechnology

+86-13524779951

sales@xmobio.com

Products

BIOACTIVE COMPOUND

Anti-tumor series

Antithrombotic series

Anti-HCV series

Rheumatism series

Anti-diabetic series

Nervous system series

Others

intermediate

Featured products

Others

This product is in stock，please ask for price.
If you have any question, please send the email to sales@xmobio.com for the availability.We will reply to you as soon as possible.
Shipment: Products are shipped via FedEx Express.

Products

Description

Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of cancer . The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer.

Chemical Structure

Chemical Name

2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol

SMILES Code

CC(O)(C)CNC1=NC(C2=NC(C(F)(F)F)=CC=C2)=NC(NC3=CC(C(F)(F)F)=NC=C3)=N1

Theoretical Analysis

XingMo Cat#:XM148
Product Name:Enasidenib (AG-221)
Synonyms:AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007; Enasidenib
CAS#:1446502-11-9
Chemical Formula:C₁₉H₁₇F₆N₇O
Exact Mass:473.13988
Molecular Weight:473.38

Technical Data

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

WARNING: This product is for research use only, not for human or veterinary use

Tel: +8613524779951 QQ: