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| 产品描述 |
| AZD5363 is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AKT inhibitor AZD5363 binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components. |
| 化学结构 |
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| 化学名称 |
| (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide |
| SMILES Code |
| O=C(C1(N)CCN(C2=C3C(NC=C3)=NC=N2)CC1)N[C@H](C4=CC=C(Cl)C=C4)CCO |
| 基本信息 |
产品编号:XM106
产品名称:AZD-5363
别名:AZD5363; AZD-5363; AZD 5363.
CAS#:1143532-39-1
分子式:C21H25ClN6O2
精确分子量:428.17275
分子量:428.9152
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| 物化性质 |
外观: 白色固体
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存
药物剂型: 可以DMSO 配制。 |
该产品只供科研使用，不能给病人提供。
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