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| 产品描述 |
| LXH254 is an adenosine triphosphate (ATP)-competitive inhibitor of BRAF (also referred to herein as b-RAF or b-Raf) and CRAF (also referred to herein as c-RAF or c- Raf) protein kinases. Throughout the present disclosure, LXH254 is also referred to as a c-RAF (or CRAF) inhibitor or a C-RAF/c-Raf kinase inhibitor. In cell-based assays, LXH254 has demonstrated anti-proliferative activity in cell lines that contain a variety of mutations that activate MAPK signaling. Moreover, LXH254 is a Type 2 ATP -competitive inhibitor of both B-Raf and C-Raf that keeps the kinase pocket in an inactive conformation, thereby reducing the paradoxical activation seen with many B-Raf inhibitors, and blocking mutant RAS-driven signaling and cell proliferation[ |
| 化学结构 |
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| 化学名称 |
| N-{3-[2-(2-Hydroxy-ethoxy)-6-morpholin-4-yl-pyridin-4-yl]-4-methyl-phenyl}-2-trifluoromethyl-isonicotinamide |
| 基本信息 |
产品编号:XM730
产品名称:LXH254
别名:LXH254, LXH-254
CAS#:1800398-38-2
分子式:C25H25F3N4O4
精确分子量:502.18
分子量:502.49
纯度:>98%
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| 物化性质 |
外观: 固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存 |
该产品只供科研使用，不能给病人提供。
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