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| 产品描述 |
| Ravoxertinib also known as GDC-0994 and RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. |
| 化学结构 |
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| 化学名称 |
| (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one |
| SMILES Code |
| O=C1C=C(C2=NC(NC3=CC=NN3C)=NC=C2)C=CN1[C@@H](C4=CC=C(Cl)C(F)=C4)CO |
| 基本信息 |
产品编号:XM093
产品名称:GDC-0994, Ravoxertinib
别名:GDC0994; GDC-0994; GDC 0994; RG7842; RG-7842; RG 7842; Ravoxertinib
CAS#:1453848-26-4
分子式:C21H18ClFN6O2
精确分子量:440.11638
分子量:440.86
纯度:>98%
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| 物化性质 |
外观: 类白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存
药物剂型: 可以DMSO 配制。 |
该产品只供科研使用，不能给病人提供。
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