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| 产品描述 |
| Soluble guanylate cyclase （sGC） is the primary cellular receptor for nitric oxide （NO）. NO binds and activates a heme group in sGC， initiating the conversion of GTP to the second messenger cyclic GMP （cGMP）. BAY-41-8543 is a heme-dependent stimulator of sGC， increasing the activity of recombinant sGC dose-dependently， from 0.1 nM to 100 uM， up to 92-fold. Surprisingly， NO donors synergize with BAY-41-8543 in stimulating recombinant sGC. BAY-41-8543 relaxes vessels and inhibits platelet aggregation in vitro at nM concentrations. In vivo， BAY-41-8543 decreases blood pressure dose-dependently， prolongs bleeding time， and reduces thrombosis. Inhalation of microparticles containing BAY-41-8543 increases pulmonary vasodilation without changing mean arterial pressure， suggesting that agonists of sGC may be efficacious in treating pulmonary hypertension. |
| 化学结构 |
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| 化学名称 |
| 2-[1-[（2-fluorophenyl）methyl]-1H-pyrazolo[3，4-b]pyridin-3-yl]-5-（4-morpholinyl）-4，6-pyrimidinedia |
| 基本信息 |
产品编号:XM718
产品名称:BAY-41-8543
别名:BAY-41-8543
CAS#:256498-66-5
分子式:C21H21FN8O
分子量:420.4499
纯度:>98%
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| 物化性质 |
外观: 固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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