产品描述

SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. SHP099 exhibits dose-dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/PD-L1).

化学结构

化学名称

6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine

SMILES Code

NC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl

基本信息

产品编号:XM708  产品名称:SHP099 free base  别名:SHP099; SHP-099; SHP 099.  CAS#:1801747-42-1 (free base)  分子式:C16H19Cl2N5  精确分子量:351.1018  分子量:352.263  纯度:>98%

物化性质

该产品只供科研使用，不能给病人提供。