产品描述

BMS-986020, also known as AM152 and AP-3152 free acid, is a potent and selective LPA1 antagonist. BMS-986020 is in Phase 2 clinical development for treating idiopathic pulmonary fibrosis. BMS-986020 selectively inhibits the LPA receptor, which is involved in binding of the signaling molecule lysophosphatidic acid, which in turn is involved in a host of diverse biological functions like cell proliferation, platelet aggregation, smooth muscle contraction, chemotaxis, and tumor cell invasion, among others.

化学结构

化学名称

(R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid

SMILES Code

O=C(C1(C2=CC=C(C3=CC=C(C4=C(NC(O[C@H](C)C5=CC=CC=C5)=O)C(C)=NO4)C=C3)C=C2)CC1)O

基本信息

产品编号:XM707  产品名称:BMS-986020  别名:BMS-986020; BMS986020; BMS 986020; AP-3152 free acid; AM152; AM 152; AM-152.  CAS#:1257213-50-5  分子式:C29H26N2O5  精确分子量:482.1842  分子量:482.536  纯度:>98%

物化性质

该产品只供科研使用，不能给病人提供。