产品描述

Firategrast, also known as SB-683699 or T-0047, is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS). This could decrease multiple sclerosis (MS) activity, but may compromise CNS immune surveillance. The integrins are a sort of transmembrane receptors that modulate the signal transduction from ECM to the cell. They are associated with a lot of diseases such as cancer, inflammation and thrombotic diseases.

化学结构

化学名称

(2S)-2-[(2,6-difluorobenzoyl)amino]-3-[4-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]phenyl]propanoic acid

SMILES Code

O=C(O)[C@@H](NC(C1=C(F)C=CC=C1F)=O)CC2=CC=C(C3=C(OC)C=C(COCC)C=C3OC)C=C2

基本信息

产品编号:XM704  产品名称:Firategrast  别名:SB-683699; SB 683699; SB683699; T-0047; T 0047; T0047; Firategrast  CAS#:402567-16-2  分子式:C27H27F2NO6  精确分子量:499.1806  分子量:499.5108  纯度:>98%

物化性质

该产品只供科研使用，不能给病人提供。