产品描述

Lifitegrast, also known as SAR-1118, is an LFA-1 antagonist intended for the treatment of vascular complications of the eye. Lifitegrast inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses.

化学结构

化学名称

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

SMILES Code

O=C(O)[C@@H](NC(C1=C(Cl)C2=C(CN(C(C3=CC=C4C=COC4=C3)=O)CC2)C=C1Cl)=O)CC5=CC=CC(S(=O)(C)=O)=C5

基本信息

产品编号:XM702  产品名称:Lifitegrast  别名:SAR-1118; SAR 1118; SAR1118; Lifitegrast, brand name: Xiidra.  CAS#:1025967-78-5  分子式:C29H24Cl2N2O7S  精确分子量:614.0681  分子量:615.478

物化性质

该产品只供科研使用，不能给病人提供。