产品描述

Rucaparib is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis.

化学结构

化学名称

8-Fluoro-2-(4-((methylamino)methyl)phenyl)-1,3,4,5-tetrahydro-6H-azepino(5,4,3-cd)indol-6-one

SMILES Code

O=C1NCCC2=C(C3=CC=C(CNC)C=C3)NC4=C2C1=CC(F)=C4

基本信息

产品编号:XM701  产品名称:Rucaparib free base  别名:Rucaparib free base, AG-14447; AG 14447; AG14447; Rubraca.  CAS#:283173-50-2  分子式:C19H18FN3O  精确分子量:323.1434  分子量:323.3714  纯度:>98%

物化性质

该产品只供科研使用，不能给病人提供。