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| 产品描述 |
| CC0651 is an allosteric inhibitor of the human cdc34 ubiquitin-conjugating enzyme that potently (IC50 = 1.72 uM) inhibited the ubiquitination of p27 Kip1.Target: hcdc34 ubiquitin-conjugating enzyme CC0651 that potently (IC50 = 1.72 uM) inhibited the ubiquitination of p27 Kip1, as confrmed by dose-response analysis. CC0651 corresponds to (2R,3S,4S)-5-(3,5-dichlorobiphenyl-4-yl)-2,3-dihydroxy-4-(2-methoxyacetamido) pentanoic acid and has a molecular mass of 442.3 g/mol.The calculated Log P and Log D values for CC0651 were 2.46 and 0.985, with an aqueous solubility of 1 mg/ml at pH 7.4. CC0651 had no effect on ubiquitination of the yeast CDK inhibitor Sic1 in the yeast Cdc34-SCF Cdc4 reaction. However, substitution of yeast Cdc34 with hCdc34 in this reaction caused CC0651 to robustly inhibit Sic1 ubiquitination. |
| 化学结构 |
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| 基本信息 |
产品编号:XM370
产品名称:CC 0651
CAS#:1319207-44-7
分子式:C20H21Cl2NO6
分子量:442.29
纯度:>98%
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| 物化性质 |
外观: 白色或类白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限: 3 年 -20℃ 固体储存 2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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