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| 产品描述 |
| DAPT, also known GSI-IX, is a potent and selective γ-secretase inhibitor. DAPT is a non-transition-state analogue GSI and is the compound most widely evaluated in experimental models. DAPT causes a reduction in Aβ levels in human primary neuronal cell cultures with IC50 values = 115−200 nM. DAPT blocks Notch signaling in a cell-based assay measuring the activation of the Notch pathway reporter gene with an IC50 = 500 nM. As an inhibitor of Notch, DAPT has also been used in the study of autoimmune and lymphoproliferative diseases. |
| 化学结构 |
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| 化学名称 |
| tert-butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate |
| SMILES Code |
| O=C(OC(C)(C)C)[C@H](C1=CC=CC=C1)NC([C@H](C)NC(CC2=CC(F)=CC(F)=C2)=O)=O |
| 基本信息 |
产品编号:XM196
产品名称:DAPT
CAS#:208255-80-5
分子式:C23H26F2N2O4
精确分子量:432.1861
分子量:432.4678
纯度:>98%
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| 物化性质 |
外观: 白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限: 3 年 -20℃ 固体储存 2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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