|
| 产品描述 |
| NU7441, also known as KU-57788, is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB. |
| 化学结构 |
 |
| 化学名称 |
| 8-(4-dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |
| SMILES Code |
| O=C1C=C(N2CCOCC2)OC3=C(C4=C5C(C6=CC=CC=C6S5)=CC=C4)C=CC=C13 |
| 基本信息 |
产品编号:XM032
产品名称:NU7441
CAS#:503468-95-9
分子式:C25H19NO3S
精确分子量:413.10856
分子量:413.49
纯度:>98%
|
| 物化性质 |
外观: 固体粉末状
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限: 3 年 -20℃ 固体储存 2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
|
|
|
