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| 产品描述 |
| GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50=0.8 nM (Wnt3a Co-culture RGA). GNF-6231 demonstrated excellent pathway inhibition and induced robust antitumor efficacy in a mouse MMTV-WNT1 xenograft tumor model. Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer. |
| 化学结构 |
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| 化学名称 |
| N-[5-(4-Acetyl-piperazin-1-yl)-pyridin-2-yl]-2-(2'-fluoro-3-methyl-[2,4']bipyridinyl-5-yl)-acetamide |
| SMILES Code |
| O=C(NC1=NC=C(N2CCN(C(C)=O)CC2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=F |
| 基本信息 |
产品编号:XM018
产品名称:GNF-6231
别名:GNF-6231; GNF 6231; GNF6231 .
CAS#:1243245-18-2
分子式:C24H25FN6O2
精确分子量:448.20
分子量:448.49
纯度:>98%
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| 物化性质 |
外观: 固体粉末状
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限: 3 年 -20℃ 固体储存 2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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