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| 产品描述 |
| AM-0902 is a potent and selective Transient Receptor Potential A1 (TRPA1) Antagonist Demonstrating Potent in Vivo Activity with pharmacokinetic properties allowing for >30-fold coverage of the rat TRPA1 IC50 in vivo. AM-0902 showed rTRPA1 45Ca2+ Flux IC50=0.071 microM and hTRPA1 45Ca2+ Flux IC50=0.131 microM. AM-0902 demonstrated dose-dependent inhibition of AITC-induced flinching in rats, validating its utility as a tool for interrogating the role of TRPA1 in in vivo pain models. |
| 化学结构 |
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| 化学名称 |
| 1-((3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1,7-dihydro-6H-purin-6-one |
| SMILES Code |
| O=C1N(CC2=NC(CCC3=CC=C(Cl)C=C3)=NO2)C=NC4=C1N(C)C=N4 |
| 基本信息 |
产品编号:XM098
产品名称:AM-0902
别名:AM-0902; AM 0902; AM0902.
CAS#:1883711-97-4
分子式:C17H15ClN6O2
精确分子量:370.830
分子量:370.797
纯度:>98%
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| 物化性质 |
外观: 固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存
药物剂型: 可以DMSO 配制。 |
该产品只供科研使用，不能给病人提供。
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