| 产品描述 |
| AMG-837 is a potent, orally bioavailable GPR40 agonist. AMG 837 was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG 837 for 21-days in Zucker fatty rats. Preclinical studies demonstrated that AMG 837 was a potent GPR40 partial agonist which lowered post-prandial glucose levels. These studies support the potential utility of AMG 837 for the treatment of type 2 diabetes. |
| 化学结构 |
 |
| 化学名称 |
| calcium (S)-3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)hex-4-ynoate hydrate |
| SMILES Code |
| CC#C[C@@H](CC([O-])=O)C1=CC=C(C=C1)OCC2=CC(C3=CC=C(C=C3)C(F)(F)F)=CC=C2.CC#C[C@@H](CC([O-])=O)C4=CC=C(C=C4)OCC5=CC(C6=CC=C(C=C6)C(F)(F)F)=CC=C5.[H]O[H].[Ca+2] |
| 基本信息 |
产品编号:XM002
产品名称:AMG-837 calcium salt hydrate
别名:AMG837; AMG-837; AMG 837
CAS#:1259389-38-2 (calium salt hydrate)
分子式:C52H42CaF6O7
分子量:932.9694
|
| 物化性质 |
外观: 固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温环境下运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限: 3 年-20℃ 固体储存
2 年 -80℃ 溶于储存 |
