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| 产品描述 |
| P505-15, also known as PRT2607, PRT062607, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. P505-15 successfully inhibited SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL. |
| 化学结构 |
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| 化学名称 |
| 4-((3-(2H-1,2,3-triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide hydrochloride |
| SMILES Code |
| O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(N4N=CC=N4)=C3)N.[H]Cl |
| 基本信息 |
产品编号:XM194
产品名称:P505-15 hydrochloride
别名:PRT2607; PRT-2607; PRT 2607; PRT062607; PRT-062607; PRT 062607; P-505-15; P 505-15; P505-15; BIIB057.
CAS#:1370261-97-4 (HCl) 1370261-96-3 (free base)
分子式:C19H24ClN9O
精确分子量:393.20256
分子量:429.913
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| 物化性质 |
外观: 白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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