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| 产品描述 |
| Momelotinib, also known as CYT387, is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM). As of 2011, CYT387 is being developed as a drug for myelofibrosis and currently undergoes Phase I/II clinical trials. Additional potential treatment indications for CYT387 include other myeloproliferative neoplasms, cancer (solid and liquid tumors) and inflammatory conditions. |
| 化学结构 |
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| 化学名称 |
| N-(cyanomethyl)-4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzamide. |
| SMILES Code |
| O=C(NCC#N)C1=CC=C(C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2)C=C1 |
| 基本信息 |
产品编号:XM085
产品名称:Momelotinib (CYT387)
别名:CTY387; CYT-387; CYT 387; CYT11387; CYT-11387; CYT 11387; Momelotinib.
CAS#:1056634-68-4
分子式:C23H22N6O2
精确分子量:414.18042
分子量:414.46
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| 物化性质 |
外观: 淡黄色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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