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| 产品描述 |
| RVX-297 is a BD2 selective inhibitor of BET bromodomains. RVX-297 is structurally related to the clinical compound RVX-208, currently undergoing phase III clinical trials for the treatment of cardiovascular diseases, but is distinctly different in its biological and pharmacokinetic profiles. RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein. Selective inhibition of either BD1 or BD2 can have significant implications on differential gene expression, which possibly can be further linked to the specific disease indication. |
| 化学结构 |
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| 化学名称 |
| 2-(3,5-dimethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one |
| SMILES Code |
| COC1=C(C(NC(C2=CC(C)=C(OCCN3CCCC3)C(C)=C2)=N4)=O)C4=CC(OC)=C1 |
| 基本信息 |
产品编号:XM360
产品名称:RVX-297
别名:RVX-297; RVX 297; RVX297.
CAS#:1044871-04-6
分子式:C24H29N3O4
精确分子量:423.2158
分子量:423.513
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| 物化性质 |
外观: 白色或类白色固体粉末
纯度: >98%
运输信息: 非危险化学品，适于常温或冰袋运输。
储存条件: 低温，干燥，避光。
溶解性: 溶于DMSO, 不溶于水
储存期限:3年 -20℃固体储存
2 年 -80℃ 溶液储存 |
该产品只供科研使用，不能给病人提供。
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